Literature

Abstract

A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good activity against Gram-positive bacteria, irrespective of the nature of the amino moiety.

DOI： 10.1016/j.bmcl.2016.03.098

Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines

Bioorganic & Medicinal Chemistry Letters 2016.0

Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide

Bioorganic & Medicinal Chemistry Letters 2007.0

Synthesis and in vitro study of novel Mannich bases as antibacterial agents

Bioorganic & Medicinal Chemistry Letters 2005.0

QSAR study on antibacterial activity of sulphonamides and derived Mannich bases

Bioorganic & Medicinal Chemistry Letters 2003.0

Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2-aminomethyl-4-substituted-1,2,4-triazoline-3-thiones

European Journal of Medicinal Chemistry 2013.0

Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity