Literature

Abstract

A series of novel 1,2,3-triazole/isoxazole functionalized pyrido[2,3-d]pyrimidine derivatives 6a-c, 7a-h and 8a-e were prepared in series of synthetic steps. All the compounds screened for the anticancer activity against four human cancer cell lines using Nocodazole as standard. Compounds 7d and 7h showed highest activity against PANC-1 (pancreatic cancer) and A549 (lung cancer) cell lines respectively and more than standard. All the compounds also screened for antibacterial activity using Rifampicin and Ciprofloxacin as standards and identified promising compounds further evaluated for minimum inhibitory concentration to validate the data.

DOI： 10.1016/j.bmcl.2016.04.038

Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3- d ]pyrimidine derivatives as promising anticancer and antibacterial agents

Bioorganic & Medicinal Chemistry Letters 2016.0

Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives

Bioorganic & Medicinal Chemistry Letters 2014.0

Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents

Bioorganic & Medicinal Chemistry Letters 2016.0

Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents

Bioorganic & Medicinal Chemistry Letters 2013.0

Synthesis of novel trifluoromethyl substituted furo[2,3- b ]pyridine and pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives as potential anticancer agents

European Journal of Medicinal Chemistry 2016.0

Synthesis of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives as potential anticancer agents