Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity Structure-Based Discovery of Substituted 4,5′-Bithiazoles as Novel DNA Gyrase Inhibitors Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes New N -phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships N-Benzyl-3-sulfonamidopyrrolidines Are a New Class of Bacterial DNA Gyrase Inhibitors New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors