Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

MedChemComm
2016.0

Abstract

Deep eutectic solvents (DESs) are a new class of green solvents used to dissolve the non-steroidal antiinflammatory drugs (NSAIDs) for potential nonaqueous liquid administration applications. Several NSAIDs are readily soluble in various DESs to a high concentration. Aspirin, a hydrolabile NSAID was 8.2-fold more stable against cleavage in DES than in water.

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