Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c Indolocarbazoles.3. Synthesis of novel aza analogs of staurosporine and K 252a as PKC inhibitors. Production of the Staurosporine Aglycon K-252c with a Blocked Mutant of the Staurosporine Producer Strain Streptomyces longisporoflavus and by Biotransformation of Staurosporine with Streptomyces mediocidicus ATCC 13279. Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c. Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ The Shurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a. Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors