Drug discovery strategies to outer membrane targets in Gram-negative pathogens

Drug discovery strategies to outer membrane targets in Gram-negative pathogens Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants A Gestalt approach to Gram-negative entry Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria Optimization of globomycin analogs as novel gram-negative antibiotics Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity Targeting mycobacterial membranes and membrane proteins: Progress and limitations