Marine sponge alkaloids as a source of anti-bacterial adjuvants

Bioorganic & Medicinal Chemistry Letters
2016.0

Abstract

Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance.

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