Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

MedChemComm
2016.0

Abstract

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the <i>Francisella tularensis</i> surrogate <i>Francisella novicida</i>. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the <i>Francisella</i> sub-species <i>F. novicida</i> and <i>F. philomiragia</i>.

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