Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells

Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing A New Target for an Old Drug: Identifying Mitoxantrone as a Nanomolar Inhibitor of PIM1 Kinase via Kinome-Wide Selectivity Modeling Fangchinoline inhibits non-small cell lung cancer metastasis by reversing epithelial-mesenchymal transition and suppressing the cytosolic ROS-related Akt-mTOR signaling pathway Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer Identification of novel ROS inducer by merging the fragments of piperlongumine and dicoumarol Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer