Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers Lead discovery and optimization of T-type calcium channel blockers Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers Synthesis and evaluation of 6-pyrazoylamido-3 N -substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639 Novel T-type calcium channel blockers: Dioxoquinazoline carboxamide derivatives Discovery of diphenyl lactam derivatives as N-type calcium channel blockers