Literature

Abstract

25 new trans-stilbene and trans-stilbazole derivatives were investigated using in vitro and in silico techniques. The selectivity and potency of the compounds were assessed using commercial ELISA test. The obtained results were incorporated into 2D QSAR assay. The most promising compound 4-nitro-3',4',5'-trihydroxy-trans-stilbene (N1) was synthetized and its potency and selectivity were confirmed. N1 was classified as preferential COX-2 inhibitor. Its ability to inhibit COX-2 in MCF-7 cell line was established and its cytotoxicity by MTT test was assessed. The compound was more cytotoxic than celecoxib within studied concentration range. Finally, the investigated trans-stilbene was docked into COX-1 and COX-2 active sites using "CDOCKER" protocol.

DOI： 10.1016/j.bmc.2017.11.027

Synthesis, in vitro and in silico evaluation of novel trans -stilbene analogues as potential COX-2 inhibitors

Bioorganic & Medicinal Chemistry 2018.0

‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors

Bioorganic & Medicinal Chemistry 2007.0

Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies

Bioorganic & Medicinal Chemistry Letters 2017.0

Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors

Bioorganic & Medicinal Chemistry Letters 2015.0

Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3- c ]pyrazol-4(1 H )-ones as potential cyclooxygenase-2 (COX-2) inhibitors

Bioorganic & Medicinal Chemistry Letters 2014.0

Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents