Nav1.7 inhibitors for the treatment of chronic pain

Nav1.7 inhibitors for the treatment of chronic pain Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na_V1.7 Discovery of Potent, Selective, and State-Dependent Na_V1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain Discovery and Optimization of Selective Na_v1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na_V1.7 with Efficacy in Rat Pain Models Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors The discovery of a potent Na_v1.3 inhibitor with good oral pharmacokinetics Substituted Indazoles as Na_v1.7 Blockers for the Treatment of Pain Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel