Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo

Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer Hedgehog inhibitors from Withania somnifera Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway