<i>Staphylococcus aureus</i> (<i>S. aureus</i>) is an asymptomatic colonizer of 30% of all human beings. While generally benign, antibiotic resistance contributes to the success of <i>S. aureus</i> as a human pathogen. Resistance is rapidly evolved through a wide portfolio of mechanisms including horizontal gene transfer and chromosomal mutation. In addition to traditional resistance mechanisms, a special feature of <i>S. aureus</i> pathogenesis is its ability to survive on both biotic and abiotic surfaces in the biofilm state. Due to this characteristic, <i>S. aureus</i> is a leading cause of human infection. Methicillin-resistant <i>S. aureus</i> (MRSA) in particular has emerged as a widespread cause of both community- and hospital-acquired infections. Currently, MRSA is responsible for 10-fold more infections than all multi-drug resistant (MDR) Gram-negative pathogens combined. Recently, MRSA was classified by the World Health Organization (WHO) as one of twelve priority pathogens that threaten human health. In this targeted mini-review, we discuss MRSA biofilm production, the relationship of biofilm production to antibiotic resistance, and front-line techniques to defeat the biofilm-resistance system.