New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling Cholinesterase inhibitory activity of chlorophenoxy derivatives—Histamine H3 receptor ligands Search for new multi-target compounds against Alzheimer’s disease among histamine H3 receptor ligands Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice Synthesis and structure–activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease