Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8 Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2- d ]isothiazole derivatives Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy Shape-based virtual screen for the discovery of novel CDK8 inhibitor chemotypes Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases