Identification of a C3′-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth

Bioorganic & Medicinal Chemistry Letters
2020.0

Abstract

A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either wild-type (BxPC3) or G12V KRAS (Capan2) mutations. A promising compound was shown to have significantly greater efficacy in the Capan2 cell line as compared to Gemcitabine, the clinical gold standard used to treat pancreatic cancer.

Knowledge Graph

Similar Paper

Identification of a C3′-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth
Bioorganic & Medicinal Chemistry Letters 2020.0
N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer
Bioorganic & Medicinal Chemistry Letters 2010.0
A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells
Bioorganic & Medicinal Chemistry Letters 2010.0
Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells
Bioorganic & Medicinal Chemistry 2022.0
Synthesis of novel 6-substituted amino-9-(β-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells
Bioorganic & Medicinal Chemistry Letters 2018.0
Anticancer evaluation of some newly synthesized N-nicotinonitrile derivative
European Journal of Medicinal Chemistry 2013.0
Synthesis of Novel 6-(4-Substituted piperazine-1-yl)-9-(β-<scp>d</scp>-ribofuranosyl)purine Derivatives, Which Lead to Senescence-Induced Cell Death in Liver Cancer Cells
Journal of Medicinal Chemistry 2012.0
Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer
Journal of Medicinal Chemistry 2009.0
Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
European Journal of Medicinal Chemistry 2018.0
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
Journal of Medicinal Chemistry 2018.0