Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT_2C Receptor Agonist for the Treatment of Obesity Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT_2CReceptor Agonists Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents Selective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT_2CReceptor Rational Drug Design Leading to the Identification of a Potent 5-HT_2C Agonist Lacking 5-HT_2B Activity Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists Indoline derivatives as 5-HT 2C receptor agonists Design and Discovery of Functionally Selective Serotonin 2C (5-HT_2C) Receptor Agonists