Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres

Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia