Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

RSC Medicinal Chemistry
2019.0

Abstract

The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

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