Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands

Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands Developments of CRBN-based PROTACs as potential therapeutic agents Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation A MedChem toolbox for cereblon-directed PROTACs De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos