Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry

Bioorganic & Medicinal Chemistry
2022.0

Abstract

In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chemistry. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and molecular docking studies.

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