Analysis of the history of the invention of the block-buster antifungal drug Fluconazole underscores the importance of agrochemical research on drug discovery and development. The multidrug resistant fungal pathogen <i>Candida auris</i> is now responsible for serious morbidity and mortality among immuno-compromised and long-term resident hospital patients globally. New drugs against <i>C. auris</i> are urgently needed. A focused screening of 1487 fungicides from the BASF agrochemical collection gave several potent inhibitors of <i>C. auris</i> with yet noncommercialized modes of action. The hits showed only minor activity loss against the azole-resistant <i>C. auris</i> strain CDC 0385 and low to moderate cytotoxicity to human HepG2 cells. Aminopyrimidine <b>4</b> showed high activity against resistant strains and selectivity in a HepG2 cells assay and is a potential hit candidate for further optimization.