Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides

Bioorganic & Medicinal Chemistry
2016.0

Abstract

This review covers recent developments in the inhibition of translocase MraY and related phospho-GlcNAc transferases WecA and TagO, and insight into the inhibition and catalytic mechanism of this class of integral membrane proteins from the structure of Aquifex aeolicus MraY. Recent studies have also identified a protein-protein interaction site in Escherichia coli MraY, that is targeted by bacteriophage ϕX174 lysis protein E, and also by cationic antimicrobial peptides containing Arg-Trp close to their N- or C-termini.

Knowledge Graph

Similar Paper

Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides
Bioorganic & Medicinal Chemistry 2016.0
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B
Bioorganic & Medicinal Chemistry 2014.0
Caprazamycins: Biosynthesis and structure activity relationship studies
International Journal of Medical Microbiology 2019.0
Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
The Journal of Antibiotics 2019.0
Elucidating the Structural Requirement of Uridylpeptide Antibiotics for Antibacterial Activity
Journal of Medicinal Chemistry 2020.0
A-102395, a New Inhibitor of Bacterial Translocase I, Produced by Amycolatopsis sp. SANK 60206
The Journal of Antibiotics 2007.0
Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY
European Journal of Medicinal Chemistry 2019.0
Mechanistic Analysis of Muraymycin Analogues: A Guide to the Design of MraY Inhibitors
Journal of Medicinal Chemistry 2011.0
A-94964, a Novel Inhibitor of Bacterial Translocase I, Produced by Streptomyces sp. SANK 60404
The Journal of Antibiotics 2008.0
Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors
Journal of the American Chemical Society 2002.0