The previously unreported 4-acetyl-benzoxamlin-2-one (II-ABOA. 1) was isolated from corn kernels. Its structure was determined by MS, NMR and X-Ray crystaIlography.In the past few decades, there has been much interest concerning the nature of disease resistance in Zea mays. Although a number of biologically active metabolites have been isolated from corn,' little is known of the implication of such metabolites in fungal resistance to species such as Fusarium. Such compounds may interfere with the enzyme trichodiene synthetase required for the formation of trichothecene mycotoxins. Some flavonoids and furanocoumarins are known to inhibit T-2 toxin biosynthesis in liquid cultures of Fusarium sporobk%ioides.2 This work describes the isolation and characterization of 4-acetyl-benzoxazolin-2-one (CABOA, 1) from kernels of a Fusarium-resistant hybrid of Zea mays. Studies are in progress to determine its antifungal activity.