In 1909, Yagi isolated the amorphous alkaloid daphnimacrine from Daphniphyllum macropodum Miquel, with no further studies on the plant's alkaloids since. We recently reported isolating several new alkaloids from this plant and establishing the structure of one (named daphnimacropine) via X-ray analysis. Given recent similar work, we summarize our results here. Column chromatography of the base fraction (217 g) on neutralized silicic acid yielded 12 fractions. Fractions 3–5 afforded three alkaloids: macrodaphnidine (I, C₂₇H₃₇O₇N), identified as yucuramine through IR, NMR, mass spectral data, and chemical reactions (revealing a tertiary hydroxyl, methoxycarbonyl, primary acetate, and secondary acetate); daphniphyllamine (II, C₃₂H₄₉O₅N), which matched daphniphylline in all physical data; and danhmacrine (C₃₄H₄₉O₄N). Fraction 9 yielded two alkaloids: macrodaphniphyllidine (III, C₂₅H₃₅O₄N) and macrodaphnine (IV, C₂₇H₃₉O₇N), a dihydro derivative of macrodaphnidine (I) confirmed by mass spectrometry. From fraction 11, two alkaloids were isolated: daphnamacropodine (C₃₂H₅₁O₄N) and macrodaphniphyllamine (V, C₂₃H₃₃O₄N), whose structure was assigned based on spectroscopic evidence and biogenetic considerations. The alkaloids whose structures are not shown here are currently under investigation.