<jats:title>Abstract</jats:title><jats:p>A new purine derivative, 3‐(3‐methylbut‐2‐en‐1‐yl)isoguanine (<jats:bold>1</jats:bold>), and a new cleistanthane‐type diterpenoid glucoside, 19‐hydroxyspruceanol 19‐<jats:italic>O</jats:italic>‐<jats:italic>β</jats:italic>‐<jats:sc>D</jats:sc>‐glucopyranoside (<jats:bold>2</jats:bold>), together with eight known compounds were isolated from the whole plant of <jats:italic>Phyllanthus reticulatus.</jats:italic> The structures were elucidated by chemical and spectroscopic methods.