Tokaramide A,a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng/mL.

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