Theonellamides A-E, cytotoxic bicyclic peptides, from a marine sponge Theonella sp.

The Journal of Organic Chemistry
1995.0

Abstract

Five new cytotoxic peptides, related to theonellamide F (1), were isolated from a marine sponge Theonella sp. Theonellamide A (2) and B (3) differ from F (1) in three amino acid residues. Additionally, theonellamide A (2) bears a β-D-galactose linked to the free imidazole nitrogen. Theonellamide C (4) is debromo 1. Theonellamide D (5) and E (6) are the β-L-arabinoside and β-D-galactoside of 1. Structures 2-6 were assigned on the basis of spectral data and chromatographic analyses of degradation products.

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