Acetylenic Acids Inhibiting Azole-Resistant Candida albicans from Pentagonia gigantifolia

Journal of Natural Products
2003.0

Abstract

Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.

Knowledge Graph

Similar Paper

Acetylenic Acids Inhibiting Azole-Resistant <i>Candida </i><i>a</i><i>lbicans </i>from <i>Pentagonia </i><i>g</i><i>igantifolia</i>
Journal of Natural Products 2003.0
Potent In Vitro Antifungal Activities of Naturally Occurring Acetylenic Acids
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Activities of Retigeric Acid B Alone and in Combination with Azole Antifungal Agents against Candida albicans
Antimicrobial Agents and Chemotherapy 2009.0
Antifungal Agents from the Roots of <i>Cudrania </i><i>c</i><i>ochinchinensis</i> against <i>Candida</i>, <i>Cryptococcus</i>, and <i>Aspergillus</i> Species
Journal of Natural Products 2003.0
New Antifungal Bithienylacetylenes from Blumea obliqua
Journal of Natural Products 1995.0
Synthesis and Antifungal Activity of Chromones and Benzoxepines from the Leaves of <i>Ptaeroxylon obliquum</i>
Journal of Natural Products 2020.0
PF1163A and B, New Antifungal Antibiotics Produced by Penicillium sp. I. Taxonomy of Producing Strain, Fermentation, Isolation and Biological Activities.
The Journal of Antibiotics 2000.0
Macrolides from a Marine-Derived Fungus, <i>Penicillium meleagrinum</i> var. <i>viridiflavum</i>, Showing Synergistic Effects with Fluconazole against Azole-Resistant <i>Candida albicans</i>
Journal of Natural Products 2016.0
Macrolides from a Marine-Derived Fungus, <i>Penicillium meleagrinum</i> var. <i>viridiflavum</i>, Showing Synergistic Effects with Fluconazole against Azole-Resistant <i>Candida albicans</i>
Journal of Natural Products 2016.0
Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938
The Journal of Antibiotics 2005.0