Three alkaloids, acosmine 1, acosmine acetate 2 and panacosmine 3 with a novel diazaadamantane skeleton and an unusual N-acetyl enamine moiety, have been isolated from the seeds of Acosmium panamense (Benth.). The structures were assembled on the basis or COSY, HMQC and HMBC data with the assistance of the LSD structure elucidation program. Proton-nitrogen HMBC experiments support the proposed structures. Other isolated compounds include 4 alpha-angeloyloxy-3 beta-hydroxy-13 beta-methoxylupanine 4, a new compound and the known alkaloids lupanine and multiflorine. (C) 1999 Elsevier Science Ltd. All rights reserved.