Marine fungi are a rich source of biologically active compounds of various nature [1, 2]. In continuation of research on secondary metabolites from marine-fungus isolates, we investigated the strain Aspergillus fumigatus KMM 4631, which was isolated from a soft coral Simularia sp. (Kunashir island, Kuril islands, 52 m deep). The strain was cultivated on modified rice medium [3] for 21 days, and the mycelium together with the medium was ground and extracted three times with CHCl3:alcohol (2:1), followed by chromatography over silica gel L and separation by HPLC to afford five compounds (1–5). Their structures were identified as verruculogen (1), cyclotryprostatin A (2), cyclotryprostatin B (3), 12,13-dihydroxyfumitremorgin C (4), and fumitremorgin C (5) by comparison of spectral data (EI-MS, PMR, 13C NMR) with literature reports. It has been found that 1–5 at concentrations of 10.0–50.0 µg/mL stop division of fertilized egg cells of the sea urchin Strongylocentrotus intermedius at the stage of 1–4 blastomers, with unhydroxylated fumitremorgin C (5) being the most active (IC50 = 10 µg/mL). Compounds 1–5 also exhibit cytotoxic activity toward Erlich carcinoma tumor cells in vitro (IC50 = 20–50 µg/mL). Thus, the marine isolate of A. fumigatus KMM 4631 is a good producer of fumitremorgins, potential antitumor preparations [9], and the yields of cyclotryprostatins A and B were three orders of magnitude greater than the previously reported yields of these compounds [7].