From the herbaceous periwinkle (Vinca herbacea, Waldst. et Kit.) (family Apocynaceae) growing in Georgia we have isolated an alkaloid in the form of white acicular crystals with mp 224-226°C, [~]~o _18 ° (c 1.1; pyridine). The PMR spectrum of the alkaloid has a group of signals in the weak-field region (aromatic and -O-CH protons), two singlets of methoxy groups at 3.71 and 3.63 ppm, and a doublet from a C-methyl group at 1.33 ppm. The mass spectrum of the compound showed the following main peaks: of the molecular ion with m/e 382, of fragments formed from the molecular ion with m/e 367, 351, 323, 214, and 200, of ions with m/e 297, 281, 253, and 199 arising from the (M -- i) ~ ion, and of ions with m/e 186 and 295 formed from the ions with m/e 214 and 297, respectively. A comparison of the results of spectral analysis and the physicochemical indices of the compound that we have isolated with those alkaloids of the heteroyohimban group enabled it to be identified as isoreserpinine. This is the first time that isoreserpinine has been isolated from plants of the genus Vinca.