A camptothecin derivative from nothapodytes foetida

Phytochemistry
1988.0

Abstract

A novel camptothecin derivative was isolated from the wood of Nothapodytes foetida. Its structure was elucidated by spectral data as (20S)-18,19-dehydrocamptothecin; Apart from other already known components, two eudesmane-type alcohols, two coumarins and a new spiroketalenolether-type acetylene were isolated from Santolina rosmarinifolia subspecies rosmarinifolia and canescens. The structures assigned were based on their spectral properties. The relative stereochemistries of the new acetylene at C-11 and that of the known spiroacetalenic acetylenes were assigned by NMR-NOE experiments.

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