Dysinosins B−D, Inhibitors of Factor VIIa and Thrombin from the Australian SpongeLamellodysideachlorea

Journal of Natural Products
2004.0

Abstract

Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.

Knowledge Graph

Similar Paper

Dysinosins B−D, Inhibitors of Factor VIIa and Thrombin from the Australian Sponge<i>Lamellodysidea</i><i>c</i><i>hlorea</i>
Journal of Natural Products 2004.0
Dysinosins B−D, Inhibitors of Factor VIIa and Thrombin from the Australian Sponge<i>Lamellodysidea</i><i>c</i><i>hlorea</i>
Journal of Natural Products 2004.0
Dysinosin A:  A Novel Inhibitor of Factor VIIa and Thrombin from a New Genus and Species of Australian Sponge of the Family Dysideidae
Journal of the American Chemical Society 2002.0
Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa
Journal of Medicinal Chemistry 2008.0
Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, <i>Coscinoderma </i><i>m</i><i>athewsi</i>
Journal of Natural Products 1998.0
Three more cyclotheonamides, C, D, and E, potent thrombin inhibitors from the marine sponge Theonella swinhoei
Bioorganic &amp; Medicinal Chemistry 1995.0
Haterumadysins A−D, Sesquiterpenes from the Okinawan Marine Sponge <i>Dysidea </i><i>c</i><i>hlorea</i>
Journal of Natural Products 2006.0
Cyclotheonamides E2 and E3, New Potent Serine Protease Inhibitors from the Marine Sponge of the Genus <i>Theonella</i>
Journal of Natural Products 1998.0
Cyclotheonamides E2 and E3, New Potent Serine Protease Inhibitors from the Marine Sponge of the Genus <i>Theonella</i>
Journal of Natural Products 1998.0
Two novel alkaloids from the South China Sea marine sponge Dysidea sp.
The Journal of Antibiotics 2010.0