Micropeptin 90, a plasmin and trypsin inhibitor from the blue-green alga Microcystis aeruginosa (NIES-90)

Tetrahedron Letters
1995.0

Abstract

Micropeptin 90, a plasmin and trypsin inhibitor, was isolated from the cultured freshwater blue-green alga Microcystis aerug/nosa (NIES-90). Its structure was elucidated to be I on the basis of 2D NMR data and chemical degradation. This cyclic depsipeplide inhibited plasmin and trypsin potently with ICs0 of 0.1 and 2.0 I.tg/ml, respectively.

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