Aeruginosins 98-A and B, trypsin inhibitors from the blue-green alga Microcystis aeruginosa (NIES-98)

Tetrahedron Letters
1995.0

Abstract

Aeruginosins 98-A and B, trypsin inhibitors, were isolated from the cultured freshwater blue-green alga Microcystis aeruginosa. Their structures were elucidated to be 1 and 2 respectively on the basis of 2D NMR data and chemical degradation. These peptides inhibited trypsin potently with an IC50 of 0.6 μg/ml.

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