<jats:title>Abstract</jats:title><jats:p>We report a genomics‐guided exploration of the metabolic potential of the brasilicardin producer strain <jats:italic>Nocardia terpenica</jats:italic> IFM 0406. Bioinformatics analysis of the whole genome sequence revealed the presence of a biosynthetic gene cluster presumably responsible for the generation of formerly unknown nocobactin derivatives. Mass spectrometry‐assisted isolation led to the identification of three new siderophores, terpenibactins A (<jats:bold>1</jats:bold>), B (<jats:bold>2</jats:bold>) and C (<jats:bold>3</jats:bold>), which belong to the class of nocobactins. Their structures were elucidated by employing spectroscopic techniques. Compounds <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> demonstrated inhibitory activity towards the muscarinic M3 receptor, while exhibiting only a low cytotoxicity.