Four natural products with the aflavinine ring system (1 and 3-5) have been isolated as major components of the sclerotia (key survival structures) produced by several isolates of the common fungus Aspergillus flavus. These metabolites are selectively allocated to the sclerotia and exhibit antifeedant activity against fungivorous insects which commonly encounter sclerotia in nature. All four compounds were characterized and identified by NMR and mass spectral analysis, and three of them (3-5) have not been previously reported, despite extensive chemical studies of Aspergillus spp.