Cylindramide: Cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata Tanita & Hoshino

Tetrahedron Letters
1993.0

Abstract

A cytotoxic tetramic acid lachun named cylindramide (1) has been isolated from the marine sponge Hultihondria cylindrorn. The S~JC%W was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetrarnic acid and a eisubstituted bicyclo[3. 3. OJoctene. This lactam was cytotoxic against Bl6 melanoma cells with an IQ0 of 0.8 pg/mL.

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