The pyrrolizidine alkaloids of Heliotropium keralense have been isolated and characterized. They are iso-lycopsamine, a new pyrrolizidine ester alkaloid, intermedine and retronecine. iso-Lycopsamine was formulated as 1,2-dehydro-1-hydroxymethyl-7β-(+)-viridifloroxy-8α-pyrrolizidine on the basis of spectroscopic measurements and hydrolysis. © 1990.