Isolation and structure determination of the minor alkaloids of Heliotropium curassavicum are described. These include the new pyrrolizidine alkaloids, heliocurassavine [isoretronecanol (−) curassavine], heliocoromandaline [isoretronecanol (+) viridiflorate], heliocurassavicine [isoretronecanol (−) trachelanthate], heliocurassavinine [laburnine (−) trachelanthate], curassavinine [supinidine (−) curassavate], coromandalinine [supinidine (+) viridifloratel, heliovinine [supinidine (−) trachelanthate] and curassanecine [1-(α-hydroxy-methyl)-8α pyrrolizidin-1β-ol]. Structures were established by high resolution 1H NMR, mass spectrometry and paper electrophoresis of the alkaloids and their hydrolysis products. © 1982, All rights reserved.