<jats:title>Abstract</jats:title><jats:p>One new cinnamamide, beecheyamide (<jats:bold>1</jats:bold>) and one new lignan, (+)‐beechenol (<jats:bold>2</jats:bold>), together with fifty‐six known compounds, have been isolated from the stem of <jats:italic>Zanthoxylum beecheyanum</jats:italic>. The known compounds included seven coumarins, six benzo[<jats:italic>c</jats:italic>]phenanthridines, ten quinoline derivatives, five benzenoids, three aporphines, four amides, seven lignans, four steroids, one chlorophyll, five terpenoids, and five other compounds. The structures of these compounds were determined by means of spectral analyses. Several isolates exhibited significant antiplatelet activities.