From the stem bark of Zanthoxylum thomense a new amide, zanthomamide has been isolated and characterized as N-methyl, N-cinnamyl-(3',4'-methylenedioxy)-phenylethylamine. Other constituents identified are the known benzophenanthridines, decarine, norchelerythrine and angoline.The genus Zanthoxylum (including Fagara) is known to contain various components such as terpenes, lignans, amides and alkaloids [1]. We report here the examination of the stem bark of Zanthoxylum thomense (Engl.) A. Chev. ex Waterm. [2], a woody rutaceous plant indigenous to West Equatorial Africa.