This study investigated the lignans from the leaves of Premna recinosa (Verbenaceae). Seven hundred and fifty grams of powdered leaves were extracted with cold ethanol for 2 weeks, and the resulting residue was fractionated using vacuum liquid chromatography (VLC) on silica gel with petroleum ether-EtOAc mixtures of increasing polarity. The 50-70% EtOAc fractions were combined and subjected to Sephadex LH-20 column chromatography to obtain a mixture of three lignans, which were further purified by repetitive preparative thin-layer chromatography (prep. TLC) using CHCl3-MeOH (9:1) to yield 2 mg of (+)-1-hydroxypinoresinol, 10 mg of (+)-lariciresinol, and 7 mg of (-)-seco-isolariciresinol. The structures of these compounds were established based on spectroscopic data. This is the first report of mono- and bisfuranoid lignans in the genus Premna; such compounds have previously been reported from other genera of the Verbenaceae. Nor-lignans of the type found in Premna latifolia were not detected.