Isolation and structures of istamycin components

Carbohydrate Research
1982.0

Abstract

In addition to istamycin A and B previously isolated from culture filtrates of Streptomyces tenjimariensis, istamycin C, A₀, B₀, C₀, A₁, B₁, C₁, and A₂ which contain the 1,4-diaminocyclitol moiety, have been found as minor components. Isolation and structural elucidation of these antibiotics are described. Istamycin A₀, B₀, and C₀ are deglycyl derivatives, and istamycin A₁, B₁, and C₁ are 2″-N-formyl derivatives, of istamycin A, B, and C, respectively. Istamycin A₂ is 2″-N-carbamoylistamycin A.

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