CETP inhibitory activity of ceramides, isolated from the gorgonian Acabaria Undulata

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Four ceramides, isolated from the gorgonian Acnbaria Undulatn, and sphingosine analogs exhibited significant cholesteryl ester transfer protein (CETP) inhibitory activity. The ceramides 1,2,3,4 and N,N-dimethylsphingosine inhibited human CETP with IC50 values of 46.8,57.3,86.3,65.6 and 6.3 FM, respectively. 0 1997 Elsevier Science Ltd.

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