Octandrenolone and five novel related dimethylpyran acetophenones have been isolated from the chloroform extract of roots of Melicope erromangensis and identified by spectroscopic studies and chemical correlations as O-methyloctandrenolone, (+)-trans-3''', 4'''-dihydro-3''', 4'''-dihydroxy-O-methyloctandrenolone, (+)-trans-3 '', 4 ''-dihydroxy-O-methyloctandrenolone, (+)-trans-3''', 4'''-dihydroxyoctandrenolone, and trans-3 '', 4-''-3 '', 4 ''-dihydroxyoctandrenolone. In addition, four known quinolines and three known flavones been isolated.