Odobromoamide, a Terminal Alkynyl Bromide-Containing Cyclodepsipeptide from the Marine Cyanobacterium Okeania sp.

Bulletin of the Chemical Society of Japan
2017.0

Abstract

<jats:title>Abstract</jats:title> <jats:p>The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the novel cyclodepsipeptide odobromoamide (1). The gross structure of 1 was determined by spectroscopic analyses, and its absolute stereochemistry was determined using a variety of different methods, including chemical derivatization and degradation followed by HPLC analysis. In addition, odobromoamide (1) exhibited broad-spectrum cytotoxicity against a human cancer cell line panel.

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