Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis

Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A–E New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060 Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster Targeted Discovery of Polycyclic Tetramate Macrolactams from an Environmental <i>Streptomyces</i> Strain Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase Native and Engineered Clifednamide Biosynthesis in Multiple <i>Streptomyces</i> spp.